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What is the effect of the autoimmune disease myasthenia gravis on muscles?

Increased muscle strength

Fatigue and weakness of voluntary muscles

Myasthenia gravis is characterized by an autoimmune response that targets the communication between nerves and muscles, specifically blocking or destroying nicotinic acetylcholine receptors at the neuromuscular junction. This leads to a disruption in the normal transmission of nerve signals to muscle fibers. As a result, individuals with this condition experience significant fatigue and weakness in their voluntary muscles, particularly during activities that require sustained muscle use.

The nature of the muscle weakness in myasthenia gravis often worsens with activity and improves with rest, which is a distinctive aspect of this disease. Over time, even minor tasks can become increasingly difficult, highlighting the profound impact of the disease on muscle function. Understanding the specific effects of myasthenia gravis underscores its clinical management and the need for therapies that enhance neuromuscular transmission.

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Muscle stiffness

Excessive muscle growth

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